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This itselfalso appears multifactorial, with roles for aminergic and neu-rotrophin decline, and where increased CNS infl ammationmight also play a role, but this has until recently been mini-mally probed, both in clinical and preclinical approaches(Cribbs et al., 2012).

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Ubiquitin is a 76 amino acid pro-tein that is conjugated to lysines in target proteins either as monoubiquitination,which can occur as single ubiquitins on multiple sites or chains of up to threeubiquitin molecules on each site, or as polyubiquitination which is designated aschains of at least 4 ubiquitin molecules linked together on one or more lysines(reviewed in [ 24]). (2008) TDP-43 protein inplasma may index TDP-43 brain pathology in Alzheimer’s dis-ease and frontotemporal lobar degeneration. Theynoted a signi?cant negative correlation betweengestational age and PaCO 2. Interviewing is the means bywhich subjective data are gathered. Strauss BE, Shivakumar C, Deb SP, Deb S, Haas M (1995) The MDR1 downstream promotercontains sequence-specic binding sites for wild-type p53

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